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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CLCN6
All Species:
19.39
Human Site:
S221
Identified Species:
32.82
UniProt:
P51797
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.23
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P51797
NP_001277.1
869
97217
S221
L
P
Q
F
Q
S
I
S
L
R
K
I
Q
F
N
Chimpanzee
Pan troglodytes
XP_514393
802
89426
A180
D
F
V
S
A
G
A
A
A
G
V
A
A
A
F
Rhesus Macaque
Macaca mulatta
XP_001104721
869
97094
S221
L
P
Q
F
Q
S
I
S
L
R
K
I
Q
F
N
Dog
Lupus familis
XP_535404
889
99260
S240
L
P
Q
F
Q
S
I
S
L
R
K
I
Q
F
N
Cat
Felis silvestris
Mouse
Mus musculus
O35454
870
96962
S221
L
P
Q
F
Q
S
I
S
L
R
K
I
Q
F
N
Rat
Rattus norvegicus
P51799
803
88712
N181
L
L
L
W
A
T
L
N
S
A
F
V
L
V
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516296
878
97865
K228
R
L
R
T
L
V
C
K
V
L
G
V
L
F
S
Chicken
Gallus gallus
XP_417644
868
97172
S219
L
P
Q
F
Q
S
I
S
L
R
K
I
Q
F
N
Frog
Xenopus laevis
Q9W701
689
76782
T67
I
M
A
L
I
S
F
T
M
D
F
T
V
S
K
Zebra Danio
Brachydanio rerio
XP_696527
863
96883
K219
Q
F
Q
S
I
T
F
K
K
I
R
F
H
F
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_396520
803
89642
V181
L
A
L
N
F
A
P
V
L
I
G
A
I
L
V
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001193438
761
83935
P139
I
F
V
G
K
E
G
P
M
I
H
S
G
A
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P92943
792
87043
R170
I
P
G
T
L
L
F
R
T
L
I
G
K
I
F
Baker's Yeast
Sacchar. cerevisiae
P37020
779
87664
P157
A
W
K
G
H
V
S
P
F
I
I
F
M
L
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
92.2
99.4
93.3
N.A.
96.7
40.8
N.A.
81.3
93.2
22.7
82.6
N.A.
N.A.
37.9
N.A.
49.8
Protein Similarity:
100
92.2
99.8
95.1
N.A.
98.7
58
N.A.
85.3
97.8
39.1
90.7
N.A.
N.A.
57.3
N.A.
64.6
P-Site Identity:
100
0
100
100
N.A.
100
6.6
N.A.
6.6
100
6.6
13.3
N.A.
N.A.
13.3
N.A.
0
P-Site Similarity:
100
6.6
100
100
N.A.
100
40
N.A.
33.3
100
26.6
26.6
N.A.
N.A.
20
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
30
22.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
48.6
42.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
8
0
15
8
8
8
8
8
0
15
8
15
0
% A
% Cys:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
22
0
36
8
0
22
0
8
0
15
15
0
50
15
% F
% Gly:
0
0
8
15
0
8
8
0
0
8
15
8
8
0
8
% G
% His:
0
0
0
0
8
0
0
0
0
0
8
0
8
0
0
% H
% Ile:
22
0
0
0
15
0
36
0
0
29
15
36
8
8
8
% I
% Lys:
0
0
8
0
8
0
0
15
8
0
36
0
8
0
8
% K
% Leu:
50
15
15
8
15
8
8
0
43
15
0
0
15
15
8
% L
% Met:
0
8
0
0
0
0
0
0
15
0
0
0
8
0
0
% M
% Asn:
0
0
0
8
0
0
0
8
0
0
0
0
0
0
36
% N
% Pro:
0
43
0
0
0
0
8
15
0
0
0
0
0
0
8
% P
% Gln:
8
0
43
0
36
0
0
0
0
0
0
0
36
0
0
% Q
% Arg:
8
0
8
0
0
0
0
8
0
36
8
0
0
0
0
% R
% Ser:
0
0
0
15
0
43
8
36
8
0
0
8
0
8
8
% S
% Thr:
0
0
0
15
0
15
0
8
8
0
0
8
0
0
0
% T
% Val:
0
0
15
0
0
15
0
8
8
0
8
15
8
8
8
% V
% Trp:
0
8
0
8
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _